Ontology highlight
ABSTRACT:
SUBMITTER: Gunther S
PROVIDER: S-EPMC6321607 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Günther Sven S Bordenave Jennifer J Hua-Huy Thông T Nicco Carole C Cumont Amélie A Thuillet Raphaël R Tu Ly L Quatremarre Timothée T Guilbert Thomas T Jalce Gaël G Batteux Frédéric F Humbert Marc M Savale Laurent L Guignabert Christophe C Dinh-Xuan Anh-Tuan AT
International journal of molecular sciences 20181218 12
<h4>Background</h4>Pulmonary hypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) that significantly contributes to morbidity and mortality. Macrophage migration inhibitory factor (MIF) is a critical factor in vascular remodeling of the pulmonary circulation.<h4>Objectives</h4>We tested the effects of two small molecules targeting MIF on bleomycin (BLM)-induced collagen deposition, PH, and vascular remodeling in mouse lungs.<h4>Methods</h4>We examined the distributio ...[more]