Ontology highlight
ABSTRACT:
SUBMITTER: Oku T
PROVIDER: S-EPMC6321609 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Oku Teruaki T Shimada Kentaro K Kenmotsu Hiroki H Ando Yusuke Y Kurisaka Chisato C Sano Rikio R Tsuiji Makoto M Hasegawa Shinya S Fukui Tetsuya T Tsuji Tsutomu T
International journal of molecular sciences 20181209 12
It has recently been recognized that inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), upregulate the secretion of matrix metalloproteinase-9 (MMP-9) from cancer cells and thereby promote peritoneal dissemination. In this study, we found that TNF-α also stimulated peritoneal mesothelial cells to secrete MMP-9 as assessed by zymography. MMP-9 gene expression in mesothelial cells induced by TNF-α was confirmed by quantitative RT-PCR analysis. We then utilized the reconstituted artif ...[more]