Ontology highlight
ABSTRACT:
SUBMITTER: Odorizzi PM
PROVIDER: S-EPMC6321770 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Odorizzi Pamela M PM Jagannathan Prasanna P McIntyre Tara I TI Budker Rachel R Prahl Mary M Auma Ann A Burt Trevor D TD Nankya Felistas F Nalubega Mayimuna M Sikyomu Esther E Musinguzi Kenneth K Naluwu Kate K Kakuru Abel A Dorsey Grant G Kamya Moses R MR Feeney Margaret E ME
Science translational medicine 20181001 463
Malaria remains a significant cause of morbidity and mortality worldwide, particularly in infants and children. Some studies have reported that exposure to malaria antigens in utero results in the development of tolerance, which could contribute to poor immunity to malaria in early life. However, the effector T cell response to pathogen-derived antigens encountered in utero, including malaria, has not been well characterized. Here, we assessed the frequency, phenotype, and function of cord blood ...[more]