Detecting and interpreting DNA methylation marks.
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ABSTRACT:
SUBMITTER: Ren R
PROVIDER: S-EPMC6322410 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Detecting and interpreting DNA methylation marks.
Ren Ren R Horton John R JR Zhang Xing X Blumenthal Robert M RM Cheng Xiaodong X
Current opinion in structural biology 20180719
The generation, alteration, recognition, and erasure of epigenetic modifications of DNA are fundamental to controlling gene expression in mammals. These covalent DNA modifications include cytosine methylation by AdoMet-dependent methyltransferases and 5-methylcytosine oxidation by Fe(II)-dependent and α-ketoglutarate-dependent dioxygenases. Sequence-specific transcription factors are responsible for interpreting the modification status of specific regions of chromatin. This review focuses on rec ...[more]
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