Dataset Information

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

ABSTRACT:

Background

Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.

Methods

We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study.

Results

Fetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels. Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3], P = 0.001) and subjects with obesity (704.1 [595.5-880.9] vs. 612.2 [547.9-802.1], P = 0.016). In addition, brachial-ankle pulse wave velocity (baPWV), which reflects arterial stiffness, was higher in MA individuals compared to MH individuals. Multiple logistic regression analysis revealed that both individuals without obesity (P for trend?=?0.017) and with obesity (P for trend?=?0.028) in the higher tertiles of fetuin-A had an increased risk of MA than those in the lowest tertile.

Conclusions

This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults.

SUBMITTER: Chung HS

PROVIDER: S-EPMC6323440 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Publications

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

Chung Hye Soo HS Lee Hyun Jung HJ Hwang Soon Young SY Choi Ju-Hee JH Yoo Hye Jin HJ Seo Ji A JA Kim Sin Gon SG Kim Nan Hee NH Choi Dong Seop DS Baik Sei Hyun SH Choi Kyung Mook KM

International journal of endocrinology 20181224

<h4>Background</h4>Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.<h4>Methods</h4>We examined the association ...[more]

PMID: 30675162

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Project description:Food web structure and dynamics depend on relationships between body sizes of predators and their prey. Species-based and community-wide estimates of preferred and realized predator-prey mass ratios (PPMR) are required inputs to size-based size spectrum models of marine communities, food webs, and ecosystems. Here, we clarify differences between PPMR definitions in different size spectrum models, in particular differences between PPMR measurements weighting prey abundance in individual predators by biomass (r bio) and numbers (r num). We argue that the former weighting generates PPMR as usually conceptualized in equilibrium (static) size spectrum models while the latter usually applies to dynamic models. We use diet information from 170,689 individuals of 34 species of fish in Alaskan marine ecosystems to calculate both PPMR metrics. Using hierarchical models, we examine how explained variance in these metrics changed with predator body size, predator taxonomic resolution, and spatial resolution. In the hierarchical analysis, variance in both metrics emerged primarily at the species level and substantially less variance was associated with other (higher) taxonomic levels or with spatial resolution. This suggests that changes in species composition are the main drivers of community-wide mean PPMR. At all levels of analysis, relationships between weighted mean r bio or weighted mean r num and predator mass tended to be dome-shaped. Weighted mean r num values, for species and community-wide, were approximately an order of magnitude higher than weighted mean r bio, reflecting the consistent numeric dominance of small prey in predator diets. As well as increasing understanding of the drivers of variation in PPMR and providing estimates of PPMR in the north Pacific Ocean, our results demonstrate that that r bio or r num, as well as their corresponding weighted means for any defined group of predators, are not directly substitutable. When developing equilibrium size-based models based on bulk energy flux or comparing PPMR estimates derived from the relationship between body mass and trophic level with those based on diet analysis, weighted mean r bio is a more appropriate measure of PPMR. When calibrating preference PPMR in dynamic size spectrum models then weighted mean r num will be a more appropriate measure of PPMR.

Dataset Information

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

Background

Methods

Results

Conclusions

Publications

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes.

Similar Datasets

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