Dataset Information

Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.

ABSTRACT:

Importance

Despite reports of widespread but heterogeneous atypicality of functional connectivity in individuals with autism, little is known regarding the temporal dynamics of functional brain connections and how they relate to autistic traits.

Objective

To investigate differences in temporal synchrony between brain regions in individuals with autism and those with typical development.

Design, setting, and participants

This cohort study, conducted at the University of Utah, included 90 adolescent and adult male participants. A larger sample from the multisite Autism Brain Imaging Data Exchange (ABIDE) was also used as a replication sample. The study includes data acquired between December 2016 and April 2018. Aggregate data included in the replication sample were released to the public in August 2012 (ABIDE I) and June 2016 (ABIDE II). Data analysis were conducted between January 2018 and April 2018.

Exposures

Male individuals diagnosed as having autism (n?=?52) and typically developing male individuals (n?=?38).

Main outcomes and measures

Long duration (30 minutes/individual) of multiband, multiecho functional magnetic resonance imaging was acquired to estimate functional connectivity between brain regions. Sustained connectivity, a measure of functional connectivity duration, as well as lagged temporal dynamics related to functional connectivity, were compared between groups for 361 gray matter regions of interest and a 17-network parcellation. Lagged findings were replicated in the larger ABIDE sample (n?=?1402). Sustained connectivity findings were also associated with behavioral and cognitive variables.

Results

In 52 males with autism (mean [SD] age, 27.73 [8.66] years) and 38 control males with typical development (mean [SD] age, 27.09 [7.49] years), increases in both sustained and functional connectivity at several lags were found in individuals with autism compared with the control group. Group differences in functional connectivity were replicated in the larger ABIDE data set at a 6-second lag. Measures of symptom severity in individuals with autism were positively associated with sustained connectivity values. In the control group, sustained connectivity was negatively associated with cognitive processing. A replication sample (n?=?1402) composed of 579 individuals with autism (80 female and 499 male; mean [SD] age, 15.08 [6.89] years) and 823 in the control group (211 female and 612 male; mean [SD] age, 15.06 [6.79] years) from the ABIDE data set was also analyzed.

Conclusions and relevance

Whereas the magnitude of functional connectivity in autism is variable across brain regions, participant samples, and development, prolonged temporal synchrony of functional connections is reproducibly observed in autism, suggesting a potential mechanism for core symptoms.

SUBMITTER: King JB

PROVIDER: S-EPMC6324391 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.

King Jace B JB Prigge Molly B D MBD King Carolyn K CK Morgan Jubel J Dean Douglas C DC Freeman Abigail A Villaruz Joaquin Alfonso M JAM Kane Karen L KL Bigler Erin D ED Alexander Andrew L AL Lange Nicholas N Zielinski Brandon A BA Lainhart Janet E JE Anderson Jeffrey S JS

JAMA network open 20181102 7

<h4>Importance</h4>Despite reports of widespread but heterogeneous atypicality of functional connectivity in individuals with autism, little is known regarding the temporal dynamics of functional brain connections and how they relate to autistic traits.<h4>Objective</h4>To investigate differences in temporal synchrony between brain regions in individuals with autism and those with typical development.<h4>Design, setting, and participants</h4>This cohort study, conducted at the University of Utah ...[more]

PMID: 30646371

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Dataset Information

Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.

Importance

Objective

Design, setting, and participants

Exposures

Main outcomes and measures

Results

Conclusions and relevance

Publications

Evaluation of Differences in Temporal Synchrony Between Brain Regions in Individuals With Autism and Typical Development.

Similar Datasets

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