Ontology highlight
ABSTRACT:
SUBMITTER: Shah KN
PROVIDER: S-EPMC6324945 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Shah Khyati N KN Bhatt Roma R Rotow Julia J Rohrberg Julia J Olivas Victor V Wang Victoria E VE Hemmati Golzar G Martins Maria M MM Maynard Ashley A Kuhn Jonathan J Galeas Jacqueline J Donnella Hayley J HJ Kaushik Swati S Ku Angel A Dumont Sophie S Krings Gregor G Haringsma Henry J HJ Robillard Liliane L Simmons Andrew D AD Harding Thomas C TC McCormick Frank F Goga Andrei A Blakely Collin M CM Bivona Trever G TG Bandyopadhyay Sourav S
Nature medicine 20181126 1
Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between drug responsiveness, tolerance and resistance, especially in the absence of preexisting subclones, remains unclear. In epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells, we demonstrate that residual disease and acquired resistance in response to EGFR inhibitors requires Aurora kinase A ...[more]