Ontology highlight
ABSTRACT:
SUBMITTER: Sun F
PROVIDER: S-EPMC6325675 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sun Fengjiao F Lei Yun Y You Jingjing J Li Chen C Sun Linshan L Garza Jacob J Zhang Di D Guo Ming M Scherer Phillip E PE Lodge Daniel D Lu Xin-Yun XY
Molecular psychiatry 20180709 1
Adiponectin, a metabolic hormone secreted by adipocytes, can cross the blood-brain barrier to act on neurons in different brain regions, including those involved in stress-related disorders. Here we show that dopamine neurons in the ventral tegmental area (VTA) express adiponectin receptor 1 (AdipoR1). Intra-VTA infusion of adiponectin or the adiponectin mimetic AdipoRon in wild-type mice decreases basal dopamine neuron population activity and firing rate and reverses the restraint stress-induce ...[more]