Ontology highlight
ABSTRACT:
SUBMITTER: Gomez JA
PROVIDER: S-EPMC6440962 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nature communications 20190329 1
The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. Within neuron-astrocyte networks, astrocytes control signals from distinct afferents in a circuit-specific manner, but whether this capacity scales up to drive motivated behavior has been undetermined. Using genetic and optical dissection strategies we report that VTA astrocytes tune glutamatergic signaling selectiv ...[more]