Ontology highlight
ABSTRACT:
SUBMITTER: Fahrenbach AC
PROVIDER: S-EPMC6326526 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Fahrenbach Albert C AC Giurgiu Constantin C Tam Chun Pong CP Li Li L Hongo Yayoi Y Aono Masashi M Szostak Jack W JW
Journal of the American Chemical Society 20170622 26
We have recently shown that 2-aminoimidazole is a superior nucleotide activating group for nonenzymatic RNA copying. Here we describe a prebiotic synthesis of 2-aminoimidazole that shares a common mechanistic pathway with that of 2-aminooxazole, a previously described key intermediate in prebiotic nucleotide synthesis. In the presence of glycolaldehyde, cyanamide, phosphate and ammonium ion, both 2-aminoimidazole and 2-aminooxazole are produced, with higher concentrations of ammonium ion and aci ...[more]