Ontology highlight
ABSTRACT:
SUBMITTER: Giurgiu C
PROVIDER: S-EPMC6326530 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20171107 46
A working model of nonenzymatic RNA primer extension could illuminate how prebiotic chemistry transitioned to biology. All currently known experimental reconstructions of nonenzymatic RNA primer extension yield a mixture of 2'-5' and 3'-5' internucleotide linkages. Although long seen as a major problem, the causes of the poor regioselectivity of the reaction are unknown. We used a combination of different leaving groups, nucleobases, and templating sequences to uncover the factors that yield sel ...[more]