Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar D
PROVIDER: S-EPMC6326545 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
ACS chemical biology 20180822 9
The roles of surrounding membrane lipids in the functions of transmembrane and peripheral membrane proteins are largely unknown. Herein, we utilize the recently reported structures of the TRPV1 ion channel protein bound to its potent protein agonist, the double-knot toxin (DkTx), as a model system to investigate the roles of toxin-lipid interfaces in TRPV1 activation by characterizing a series of DkTx variants electrophysiologically. Together with membrane partitioning experiments, these studies ...[more]