Ontology highlight
ABSTRACT:
SUBMITTER: Gustmann H
PROVIDER: S-EPMC6326822 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Gustmann Henrik H Segler Anna-Lena J AJ Gophane Dnyaneshwar B DB Reuss Andreas J AJ Grünewald Christian C Braun Markus M Weigand Julia E JE Sigurdsson Snorri Th ST Wachtveitl Josef J
Nucleic acids research 20190101 1
The ability of the cytidine analog Çmf to act as a position specific reporter of RNA-dynamics was spectroscopically evaluated. Çmf-labeled single- and double-stranded RNAs differ in their fluorescence lifetimes, quantum yields and anisotropies. These observables were also influenced by the nucleobases flanking Çmf. This conformation and position specificity allowed to investigate the binding dynamics and mechanism of neomycin to its aptamer N1 by independently incorporating Çmf at four different ...[more]