Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Bautista J
PROVIDER: S-EPMC6326897 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Molecular imaging and biology 20190401 2
<h4>Purpose</h4>Foreign body reactions elicit granulomatous inflammation composed of reactive macrophages. We hypothesized that [<sup>125</sup>I]iodo-DPA-713 single-photon emission computed tomography (SPECT), a low-molecular-weight pyrazolopyrimidine ligand selectively trapped by phagocytes, could be used to detect foreign body reactions in a murine model.<h4>Procedures</h4>C57BL/6 mice intratracheally inoculated with dextran beads, which developed foreign body lesions, were imaged after inject ...[more]