Ontology highlight
ABSTRACT:
SUBMITTER: Nogalski MT
PROVIDER: S-EPMC6327058 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nogalski Maciej T MT Solovyov Alexander A Kulkarni Anupriya S AS Desai Niyati N Oberstein Adam A Levine Arnold J AJ Ting David T DT Shenk Thomas T Greenbaum Benjamin D BD
Nature communications 20190109 1
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue fr ...[more]