Ontology highlight
ABSTRACT:
SUBMITTER: Kitadate Y
PROVIDER: S-EPMC6327111 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kitadate Yu Y Jörg David J DJ Tokue Moe M Maruyama Ayumi A Ichikawa Rie R Tsuchiya Soken S Segi-Nishida Eri E Nakagawa Toshinori T Uchida Aya A Kimura-Yoshida Chiharu C Mizuno Seiya S Sugiyama Fumihiro F Azami Takuya T Ema Masatsugu M Noda Chiyo C Kobayashi Satoru S Matsuo Isao I Kanai Yoshiakira Y Nagasawa Takashi T Sugimoto Yukihiko Y Takahashi Satoru S Simons Benjamin D BD Yoshida Shosei S
Cell stem cell 20181220 1
In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells. We propose that stem cell homeostasis is achieved throu ...[more]