Ontology highlight
ABSTRACT:
SUBMITTER: Passarella D
PROVIDER: S-EPMC6327151 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Passarella Daniela D Goedert Michel M
Neurobiology of aging 20180803
The assembly of Tau into abundant β-sheet-rich filaments characterizes human tauopathies. A pathological pathway leading from monomeric to filamentous Tau is believed to be at the heart of these diseases. However, in Drosophila models of Tauopathy, neurodegeneration has been observed in the absence of abundant Tau filaments. Here we investigated the role of Tau assembly into β-sheets by expressing wild-type and Δ306-311 human Tau-383 in the retina and brain of Drosophila. We analyzed both lines ...[more]