Ontology highlight
ABSTRACT:
SUBMITTER: Xiao A
PROVIDER: S-EPMC6327951 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20180823 18
Streptococcus pneumoniae sialidase SpNanB is an intramolecular trans-sialidase (IT-sialidase) and a virulence factor that is essential for streptococcal infection of the upper and lower respiratory tract. SpNanB catalyzes the formation of 2,7-anhydro- N-acetylneuraminic acid (2,7-anhydro-Neu5Ac), a potential prebiotic that can be used as the sole carbon source of a common human gut commensal anaerobic bacterium. We report here the development of an efficient one-pot multienzyme (OPME) system for ...[more]