Ontology highlight
ABSTRACT:
SUBMITTER: Schwager S
PROVIDER: S-EPMC6328028 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Schwager Simon S Renner Silvana S Hemmerle Teresa T Karaman Sinem S Proulx Steven T ST Fetz Roman R Golding-Ochsenbein Alexandra Michaela AM Probst Philipp P Halin Cornelia C Neri Dario D Detmar Michael M
JCI insight 20181206 23
VEGF-C is an important mediator of lymphangiogenesis and has been shown to alleviate chronic inflammation in a variety of disease models. In this study, we investigated whether targeted delivery of VEGF-C to sites of inflammation and site-specific activation of lymphatic vessels would represent a clinically feasible strategy for treating chronic skin inflammation. To this end, we generated a fusion protein consisting of human VEGF-C fused to the F8 antibody (F8-VEGF-C), which is specific for the ...[more]