Ontology highlight
ABSTRACT:
SUBMITTER: Schonthaler HB
PROVIDER: S-EPMC2795522 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Schonthaler Helia B HB Huggenberger Reto R Wculek Stefanie K SK Detmar Michael M Wagner Erwin F EF
Proceedings of the National Academy of Sciences of the United States of America 20091207 50
Although(,) vascular remodeling is a hallmark of many chronic inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, anti-vascular strategies to treat these conditions have received little attention to date. We investigated the anti-inflammatory activity of systemic blockade of VEGF-A by the inhibitory monoclonal antibody G6-31, employing a therapeutic trial in a mouse model of psoriasis. Simultaneous deletion of JunB and c-Jun (DKO*) in the epidermis of ...[more]