Ontology highlight
ABSTRACT:
SUBMITTER: Wilkinson CM
PROVIDER: S-EPMC6328169 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wilkinson Cassandra M CM Fedor Brittany A BA Aziz Jasmine R JR Nadeau Colby A CA Brar Paul S PS Clark Julia J A JJA Colbourne Frederick F
PloS one 20190110 1
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function. NKCC1, a cation-chloride cotransporter, is upregulated after brain damage, such as traumatic injury and ischemic stroke. NKCC1 brings sodium and chloride into the cell, possibly worsening ion dyshomeostasis. Bumetanide, a specific NKCC1 antagonist ...[more]