Dataset Information

Single Au Atom Doping of Silver Nanoclusters.

ABSTRACT: Ag₂₉ nanoclusters capped with lipoic acid (LA) can be doped with Au. The doped clusters show enhanced stability and increased luminescence efficiency. We attribute the higher quantum yield to an increase in the rate of radiative decay. With mass spectrometry, the Au-doped clusters were found to consist predominantly of Au₁Ag₂₈(LA)₁₂^3-. The clusters were characterized using X-ray absorption spectroscopy at the Au L₃-edge. Both the extended absorption fine structure (EXAFS) and the near edge structure (XANES) in combination with electronic structure calculations confirm that the Au dopant is preferentially located in the center of the cluster. A useful XANES spectrum can be recorded for lower concentrations, or in shorter time, than the more commonly used EXAFS. This makes XANES a valuable tool for structural characterization.

SUBMITTER: van der Linden M

PROVIDER: S-EPMC6328285 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Single Au Atom Doping of Silver Nanoclusters.

van der Linden Marte M van Bunningen Arnoldus J AJ Amidani Lucia L Bransen Maarten M Elnaggar Hebatalla H Glatzel Pieter P Meijerink Andries A de Groot Frank M F FMF

ACS nano 20181203 12

Ag29 nanoclusters capped with lipoic acid (LA) can be doped with Au. The doped clusters show enhanced stability and increased luminescence efficiency. We attribute the higher quantum yield to an increase in the rate of radiative decay. With mass spectrometry, the Au-doped clusters were found to consist predominantly of Au1Ag28(LA)123-. The clusters were characterized using X-ray absorption spectroscopy at the Au L3-edge. Both the ...[more]

PMID: 30458110

Similar Datasets

Project description:Micro RNA (miR) are regulatory non-coding RNA molecules, which contain a small number of nucleotides ~18-28 nt. There are many various miR sequences found in plants and animals that perform important functions in developmental, metabolic, and disease processes. miRs can bind to complementary sequences within mRNA molecules thus silencing mRNA. Other functions include cardiovascular and neural development, stem cell differentiation, apoptosis, and tumors. In tumors, some miRs can function as oncogenes, others as tumor suppressors. Levels of certain miR molecules reflect cellular events, both normal and pathological. Therefore, miR molecules can be used as biomarkers for disease diagnosis and prognosis. One of these promising molecules is miR-21, which can serve as a biomarker with high potential for early diagnosis of various types of cancer. Here, we present a novel design of miR detection and demonstrate its efficacy on miR-21. The design employs emissive properties of DNA-silver nanoclusters (DNA/AgNC). The detection probe is designed as a hairpin DNA structure with one side of the stem complimentary to miR molecule. The binding of target miR-21 opens the hairpin structure, dramatically modulating emissive properties of AgNC hosted by the C12 loop of the hairpin. "Red" fluorescence of the DNA/AgNC probe is diminished in the presence of the target miR. At the same time, "green" fluorescence is activated and its intensity increases several-fold. The increase in intensity of "green" fluorescence is strong enough to detect the presence of miR-21. The intensity change follows the concentration dependence of the target miR present in a sample, which provides the basis of developing a new, simple probe for miR detection. The detection strategy is specific, as demonstrated using the response of the DNA/AgNC probe towards the scrambled miR-21 sequence and miR-25 molecule. Additionally, the design reported here is very sensitive with an estimated detection limit at ~1 picomole of miR-21.

Dataset Information

Single Au Atom Doping of Silver Nanoclusters.

Publications

Single Au Atom Doping of Silver Nanoclusters.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets