Ontology highlight
ABSTRACT:
SUBMITTER: Malbec R
PROVIDER: S-EPMC6328573 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Malbec Rémi R Chami Bayan B Aeschbach Lorène L Ruiz Buendía Gustavo A GA Socol Marius M Joseph Pierre P Leïchlé Thierry T Trofimenko Evgeniya E Bancaud Aurélien A Dion Vincent V
Scientific reports 20190110 1
We present µLAS, a lab-on-chip system that concentrates, separates, and detects DNA fragments in a single module. µLAS speeds up DNA size analysis in minutes using femtomolar amounts of amplified DNA. Here we tested the relevance of µLAS for sizing expanded trinucleotide repeats, which cause over 20 different neurological and neuromuscular disorders. Because the length of trinucleotide repeats correlates with the severity of the diseases, it is crucial to be able to size repeat tract length accu ...[more]