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The association between peroxisome proliferator-activated receptor ? rs3777744, rs3798343, and rs6922548 and coronary artery disease.


ABSTRACT: Objective: The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor ? (PPARD) and the risk of coronary artery disease (CAD). To this end, a prospective observational single-center study of the clinical data from 880 subjects in a Chinese population was conducted. Methods: A total of 880 subjects, including 609 CAD patients and 271 control subjects, were selected for the present study. All inpatients had 4 ml of venous blood drawn after 12 h of fasting, and then clinical tests were conducted to obtain the biochemical parameters. CAD patients and Controls were distinguished by coronary angiography. Statistical analysis was conducted with SPSS software (ver 16.0). Results: A significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased risk for CAD was found. Moreover, we found an interaction between high fasting high-density lipoprotein cholesterol (HDL-C) serum levels, low serum glucose levels and their genotypes, ultimately decreasing the risk of CAD. Haplotype analysis was conducted on the three SNP sites, rs3777744 and rs3798343 to form a block [r2 = 0.79, D' = 0.99). The A-C haplotypes were associated with an increased risk of CAD (odds ratio (OR), 95% confidence interval (CI): 1.321 (1.060-1.647), P=0.013], and the G-G haplotypes were associated with a decreased risk [OR, 95% CI: 0.714 (0.567-0.849), P=0.004]. Conclusions: Our study indicates a significant association between the G-alleles of PPARD rs3777744 and rs3798343 and a decreased CAD risk. In addition, genotypes interact with high serum HDL-C levels and low serum glucose levels, resulting in decreased prevalence of CAD.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6328892 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease.

Zhang Jing J   Liu Xiu-Lin XL   Jia Qiao-Wei QW   Zhao Chen-Hui CH   Liu Jie-Yin JY   An Feng-Hui FH   Li Li-Hua LH   Chen Zhao-Hong ZH   Wang Lian-Sheng LS   Ma Wen-Zhu WZ   Yang Zhi-Jian ZJ   Jia En-Zhi EZ  

Bioscience reports 20190103 1


<b>Objective</b>: The aim of the present study is to investigate the association between the single nucleotide polymorphism (SNP) sites of peroxisome proliferator-activated receptor Δ (PPARD) and the risk of coronary artery disease (CAD). To this end, a prospective observational single-center study of the clinical data from 880 subjects in a Chinese population was conducted. <b>Methods</b>: A total of 880 subjects, including 609 CAD patients and 271 control subjects, were selected for the presen  ...[more]

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