CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6329299 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors.
Wang X X Wang G G Shi J J Aa J J Comas R R Liang Y Y Zhu H-J HJ
The pharmacogenomics journal 20150616 3
The aim of the study was to determine the effect of carboxylesterase 1 (CES1) genetic variation on the activation of angiotensin-converting enzyme inhibitor (ACEI) prodrugs. In vitro incubation study of human liver, intestine and kidney s9 fractions demonstrated that the ACEI prodrugs enalapril, ramipril, perindopril, moexipril and fosinopril are selectively activated by CES1 in the liver. The impact of CES1/CES1VAR and CES1P1/CES1P1VAR genotypes and diplotypes on CES1 expression and activity on ...[more]
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