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Differences in patterns of care and outcomes between grade II and grade III molecularly defined 1p19q co-deleted gliomas.


ABSTRACT: Molecular markers are redefining classification of lower grade gliomas and ushering in a paradigm shift in their management. Our objective was to evaluate the differences in pattern of care and outcome by comparing grade II and grade III molecularly defined 1p19q co-deleted gliomas. We evaluated 1618 patients in the National Cancer Database diagnosed with 1p19q co-deleted gliomas from 2010 through 2014 and treated with surgery followed by radiation therapy (RT), chemotherapy (CT), or combined-modality therapy. Differences in patterns of care included that fifty-one percent of grade II tumors received surgery alone, whereas most patients with grade III tumors (86%) received surgery or biopsy followed by a form of post-operative therapy (p?p?p?

SUBMITTER: Yeboa DN 

PROVIDER: S-EPMC6329703 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Differences in patterns of care and outcomes between grade II and grade III molecularly defined 1p19q co-deleted gliomas.

Yeboa Debra Nana DN   Yu James B JB   Liao Eric E   Huse Jason J   Penas-Prado Marta M   Kann Benjamin H BH   Sulman Erik E   Grosshans David D   Contessa Joseph J  

Clinical and translational radiation oncology 20181231


Molecular markers are redefining classification of lower grade gliomas and ushering in a paradigm shift in their management. Our objective was to evaluate the differences in pattern of care and outcome by comparing grade II and grade III molecularly defined 1p19q co-deleted gliomas. We evaluated 1618 patients in the National Cancer Database diagnosed with 1p19q co-deleted gliomas from 2010 through 2014 and treated with surgery followed by radiation therapy (RT), chemotherapy (CT), or combined-mo  ...[more]

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