Ontology highlight
ABSTRACT:
SUBMITTER: Grkovic T
PROVIDER: S-EPMC6330894 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20181210 2
Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity. In the NCI-60 cancer cell assay, erythrofordins D (1) and E (2) were found to be cytotoxic in the low micro molar ranges with a mean GI<sub>50</sub> value of 2.45 and 0.71 µM, mean TGI value of 9.77 and 2.29 µM, and a mean LC<sub>50</sub> of 26.92 and 11.48 µM for 1 and 2 respectively. Using the COMPARE algor ...[more]