Project description:we report the antitumor activity of an indole alkaloid, 3alpha-acetonyltabersonine, which was isolated from Melodinus suaveolens. 3alpha-acetonyltabersonine was found to be cytotoxic to glioblastoma cell line and stem cells at low concentrations.
2017-02-28 | GSE95392 | GEO
Project description:Microsatellite in Erythrophleum fordii
Project description:Two new cassaine-type diterpenoids, namely erythrofordins D (1) and E (2), sourced from a Cameroon collection of Erythrophleum suaveolens were isolated and assessed for anti-tumor activity. In the NCI-60 cancer cell assay, erythrofordins D (1) and E (2) were found to be cytotoxic in the low micro molar ranges with a mean GI50 value of 2.45 and 0.71?µM, mean TGI value of 9.77 and 2.29?µM, and a mean LC50 of 26.92 and 11.48?µM for 1 and 2 respectively. Using the COMPARE algorithm, the new compounds were found to have similar NCI-60 response profiles to the known cardiac glycosides hyrcanoside and strophanthin. In addition, in an assay examining the viability and contractile function in human cardiomyocytes derived from induced pluripotent stem-cells, erythrofordins showed cardiotoxicity effects at concentrations as low as 0.03?µg/mL.
