Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6331161 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20181219 1
Recent research suggests that KCNQ isoforms, particularly the KCNQ4 and KCNQ5 subtypes expressed in smooth muscle cells, are involved in both establishing and maintaining resting membrane potentials and regulating smooth muscle contractility. Retigabine (RTG) is a first-in-class antiepileptic drug that potentiates neuronal KCNQ potassium channels, but poor subtype selectivity limits its further application as a pharmacological tool. In this study, we improved the subtype specificity of retigabin ...[more]