Ontology highlight
ABSTRACT:
SUBMITTER: Zhu C
PROVIDER: S-EPMC7662226 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20201101 21
Depression is a severe psychiatric disorder that affects over 100 million people worldwide. 5-HT<sub>1A</sub> receptor agonists have been implicated in the treatment of a variety of central nervous system diseases, especially depression. In this study, based on <b>FW01</b>, a selective potent 5-HT<sub>1A</sub>R agonist discovered via dynamic pharmacophore-based virtual screening, a series of indolealkylpiperazine derivatives with a benzamide moiety were designed and synthesized by the modificati ...[more]