Ontology highlight
ABSTRACT:
SUBMITTER: Morales-Nebreda L
PROVIDER: S-EPMC6331288 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Morales-Nebreda Luisa L McLafferty Fred S FS Singer Benjamin D BD
Translational research : the journal of laboratory and clinical medicine 20180809
DNA methylation is a dynamic epigenetic modification with a prominent role in determining mammalian cell development, lineage identity, and transcriptional regulation. Primarily linked to gene silencing, novel technologies have expanded the ability to measure DNA methylation on a genome-wide scale and uncover context-dependent regulatory roles. The immune system is a prototypic model for studying how DNA methylation patterning modulates cell type- and stimulus-specific transcriptional programs. ...[more]