Ontology highlight
ABSTRACT:
SUBMITTER: Korabecna M
PROVIDER: S-EPMC7566599 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Korabecna M M Zinkova A A Brynychova I I Chylikova B B Prikryl P P Sedova L L Neuzil P P Seda O O
Scientific reports 20201015 1
The cell-free DNA (cfDNA) is always present in plasma, and it is biomarker of growing interest in prenatal diagnostics as well as in oncology and transplantology for therapy efficiency monitoring. But does this cfDNA have a physiological role? Here we show that cfDNA presence and clearance in plasma of healthy individuals plays an indispensable role in immune system regulation. We exposed THP1 cells to healthy individuals' plasma with (NP) and without (TP) cfDNA. In cells treated with NP, we fou ...[more]