Cysteine Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress.
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ABSTRACT:
SUBMITTER: Fu X
PROVIDER: S-EPMC6331564 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Cysteine Disulfides (Cys-ss-X) as Sensitive Plasma Biomarkers of Oxidative Stress.
Fu Xiaoyun X Cate Shelby A SA Dominguez Melissa M Osborn Warren W Özpolat Tahsin T Konkle Barbara A BA Chen Junmei J López José A JA
Scientific reports 20190114 1
We developed a high-throughput mass spectrometry-based method to simultaneously quantify numerous small-molecule thiols and disulfides in blood plasma. Application of this assay to analyze plasma from patients with known oxidative stress (sickle cell disease and sepsis) and from a patient with sickle cell disease treated with the antioxidant N-acetylcysteine suggests that cysteine disulfides, in particular protein-bound cysteine, serve as sensitive plasma biomarkers for the extent of oxidative s ...[more]
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