Ontology highlight
ABSTRACT:
SUBMITTER: Kong B
PROVIDER: S-EPMC6331592 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kong Byoungjae B Moon Seokoh S Kim Yuna Y Heo Paul P Jung Younghun Y Yu Seok-Hyeon SH Chung Jinhyo J Ban Choongjin C Kim Yong Ho YH Kim Paul P Hwang Beom Jeung BJ Chung Woo-Jae WJ Shin Yeon-Kyun YK Seong Baik Lin BL Kweon Dae-Hyuk DH
Nature communications 20190114 1
Membrane-disrupting agents that selectively target virus versus host membranes could potentially inhibit a broad-spectrum of enveloped viruses, but currently such antivirals are lacking. Here, we develop a nanodisc incorporated with a decoy virus receptor that inhibits virus infection. Mechanistically, nanodiscs carrying the viral receptor sialic acid bind to influenza virions and are co-endocytosed into host cells. At low pH in the endosome, the nanodiscs rupture the viral envelope, trapping vi ...[more]