Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Z
PROVIDER: S-EPMC6874920 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zheng Zhen Z Li Zhefeng Z Xu Congcong C Guo Bin B Guo Peixuan P
Journal of controlled release : official journal of the Controlled Release Society 20190822
Folate (FA) receptor is a cell surface glycoprotein overexpressed on many cancer cells. It is a high affinity ligand for cancer cell targeting. However, delivery of siRNA directly through folate receptor mediated endocytosis for gene silencing has not, if any, been successful in clinical trial. We have reported the application of RNA nanotechnology to construct FA-displaying exosomes for efficient cell targeting, siRNA delivery and cancer regression (Pi et.al Nature Nanotechnology, 2018:13, 82-8 ...[more]