Ontology highlight
ABSTRACT:
SUBMITTER: Blackwood EA
PROVIDER: S-EPMC6331617 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Blackwood Erik A EA Azizi Khalid K Thuerauf Donna J DJ Paxman Ryan J RJ Plate Lars L Kelly Jeffery W JW Wiseman R Luke RL Glembotski Christopher C CC
Nature communications 20190114 1
Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases. However, this approach has not been employed in vivo. Here we show, using a mouse model of myocardial ischemia/reperfusion, that selective pharmacologic activation of the ATF6 arm of the unfolded protein response (UPR) during reperfusion, a typical clinical intervention point after myocardial infarction, transcriptionally rep ...[more]