Ontology highlight
ABSTRACT:
SUBMITTER: Barakat A
PROVIDER: S-EPMC6331823 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Barakat Assem A Al-Majid Abdullah Mohammed AM Soliman Saied M SM Lotfy Gehad G Ghabbour Hazem A HA Fun Hoong-Kun HK Wadood Abdul A Warad Ismail I Sloop Joseph C JC
Molecules (Basel, Switzerland) 20151119 11
The synthesis of the new diethyl ammonium salt of diethylammonium(E)-5-(1,5-bis(4-fluorophenyl)-3-oxopent-4-en-1-yl)-1,3-diethyl-4,6-dioxo-2-thioxohexaydropyrimidin-5-ide 3 via a regioselective Michael addition of N,N-diethylthiobarbituric acid 1 to dienone 2 is described. In 3, the carboanion of the thiobarbituric moiety is stabilized by the strong intramolecular electron delocalization with the adjacent carbonyl groups and so the reaction proceeds without any cyclization. The molecular structu ...[more]