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Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito.

ABSTRACT: A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides--adonioside A (1) and adonioside B (6)--as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-116, HepG2, HeLa, SK-OV-3, and SK-MEL-5, and SK-BR-3).

SUBMITTER: Jung JW

PROVIDER: S-EPMC6332151 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Two New Cyototoxic Cardenolides from the Whole Plants of Adonis multiflora Nishikawa & Koki Ito.

Jung Jae-Woo JW Baek Nam-In NI Hwang-Bo Jeon J Lee Seung-Su SS Park Ji-Hae JH Seo Kyeong-Hwa KH Kwon Jung-Hwa JH Oh Eun-Ji EJ Lee Dae-Young DY Chung In-Sik IS Bang Myun-Ho MH

Molecules (Basel, Switzerland) 20151123 11

A phytochemical investigation of the whole plants of Adonis multiflora Nishikawa & Koki Ito. resulted in the isolation and identification of two new cardenolides--adonioside A (1) and adonioside B (6)--as well as four known cardenolides: tupichinolide (2) oleandrine (3), cryptostigmin II (4), and cymarin (5). Their structures were elucidated on the basis of NMR, MS, and IR spectroscopic analyses. Compounds 1, 2, 5, and 6 showed significant cytotoxicity against six human cancer cell lines (HCT-11 ...[more]

PMID: 26610451

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