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Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities.

ABSTRACT: A new skeleton of diterpenoid, 1,2,3,4,4?,9,10,10?-octahydro-(4?-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4?R,9R,10?S)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (2-5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0-29.6 µM. In addition, these three compounds had significant inhibitory effects on reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-induced macrophages. Compounds 1-3 inhibited nitric oxide (NO) production in LPS-induced macrophages with IC50 values of 18.0-23.6 µM. These results showed that compounds 1, 2 had significant antioxidant and anti-inflammatory activities and might provide basis for the treatment of diseases associated with oxidative lesions and inflammation.

SUBMITTER: Zhang BB 

PROVIDER: S-EPMC6332173 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Diterpenoids from Saliva plebeia R. Br. and Their Antioxidant and Anti-Inflammatory Activities.

Zhang Bao-Bao BB   He Bai-Qiu BQ   Sun Jian-Bo JB   Zeng Biao B   Shi Xiao-Ji XJ   Zhou Yong Y   Niu Ying Y   Nie Shi-Qi SQ   Feng Feng F   Liang Yan Y   Wu Fei-Hua FH  

Molecules (Basel, Switzerland) 20150814 8

A new skeleton of diterpenoid, 1,2,3,4,4α,9,10,10α-octahydro-(4α-hydroxyymethyl) -1,1-dimethyl-9-(1-methylethyl)-(2S,3S,4αR,9R,10αS)-2,3,5,7-phenanthrenetertrol, named plebeianiol A (1), along with four known diterpenoids (2-5), were isolated from Salvia plebeia R. Br. Their structures were determined on the basis of spectral analysis. In the bioactivity tests, compounds 1, 2 and 5 showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities with IC50 values of 20.0-29.6 µM. In addi  ...[more]

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