Ontology highlight
ABSTRACT:
SUBMITTER: Wan Z
PROVIDER: S-EPMC6332188 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Wan Zhihua Z Hu Deyu D Li Pei P Xie Dandan D Gan Xiuhai X
Molecules (Basel, Switzerland) 20150629 7
A series of novel 4-thioquinazoline derivatives containing chalcone moiety were designed, synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited moderate to good anti-TMV activity. In particular, compounds M2 and M6 possessed appreciable protection activities against TMV in vivo, with 50% effective concentration (EC50) values of 138.1 and 154.8 μg/mL, respectively, which were superior to that of Ribavi ...[more]