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Potent PPAR? Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells.

ABSTRACT: Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPAR? ligand activity. They were corresponded to PPAR?-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPAR?. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter.

SUBMITTER: Lau WK

PROVIDER: S-EPMC6332226 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Potent PPARγ Ligands from Swietenia macrophylla Are Capable of Stimulating Glucose Uptake in Muscle Cells.

Lau Wai Kwan WK Goh Bey Hing BH Kadir Habsah Abdul HA Shu-Chien Alexander Chong AC Muhammad Tengku Sifzizul Tengku TS

Molecules (Basel, Switzerland) 20151212 12

Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPARγ ligand activity. They were corresponded to PPARγ-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of f ...[more]

PMID: 26703529

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