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Polyacetylenes from the Roots of Swietenia macrophylla King.

ABSTRACT: A phytochemical investigation of the roots of Swietenia macrophylla led to the isolation of seven polyacetylenes, including five new compounds (1-5) and two known ones (6-7). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds 1 and 6 showed moderate cytotoxicity against the above three human cancer cell lines with IC₅₀ values ranging from 14.3 to 45.4 ?M. Compound 4 displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC₅₀ values of 26.2 ± 0.4 and 21.9 ± 0.3 ?M, respectively.

SUBMITTER: Mi CN

PROVIDER: S-EPMC6480581 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Polyacetylenes from the Roots of Swietenia macrophylla King.

Mi Cheng-Neng CN Wang Hao H Chen Hui-Qin HQ Cai Cai-Hong CH Li Shao-Peng SP Mei Wen-Li WL Dai Hao-Fu HF

Molecules (Basel, Switzerland) 20190402 7

A phytochemical investigation of the roots of Swietenia macrophylla led to the isolation of seven polyacetylenes, including five new compounds (1-5) and two known ones (6-7). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carci ...[more]

PMID: 30987040

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