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Guignardones P-S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra.

ABSTRACT: Four new meroterpenoids, guignardones P-S (1-4), and three known analogues (5-7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.

SUBMITTER: Sun ZH

PROVIDER: S-EPMC6332344 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Guignardones P-S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra.

Sun Zhang-Hua ZH Liang Fa-Liang FL Wu Wen W Chen Yu-Chan YC Pan Qing-Ling QL Li Hao-Hua HH Ye Wei W Liu Hong-Xin HX Li Sai-Ni SN Tan Guo-Hui GH Zhang Wei-Min WM

Molecules (Basel, Switzerland) 20151221 12

Four new meroterpenoids, guignardones P-S (1-4), and three known analogues (5-7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line. ...[more]

PMID: 26703548

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