Ontology highlight
ABSTRACT:
SUBMITTER: Fu XB
PROVIDER: S-EPMC6332379 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20151013 10
In this study, two series of 3-oxo-3H-benzo[f]chromene-2-carboxylic acid derivatives (compounds 5a-i and 6a-g) were synthesized. Their in vitro proliferation inhibitory activities against the A549 and NCI-H460 human non-small cell lung cancer (NSCLC) cell lines were evaluated. Their photophysical properties were measured. Among these target compounds, 5e exhibited the strongest antiproliferative activity by inducing apoptosis, arresting cell cycle, and elevating intracellular reactive oxygen spe ...[more]