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Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution.

ABSTRACT: An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.

SUBMITTER: Hong XW

PROVIDER: S-EPMC6332461 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution.

Hong Xiao-Wei XW Zhou Yu-Qiang YQ Bai Cui-Bing CB Wang Nai-Xing NX Xing Yalan Y Zhang Wei W Wang Yan-Jing YJ Lan Xing-Wang XW Xie Yu Y Li Yi-He YH

Molecules (Basel, Switzerland) 20150918 9

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed. ...[more]

PMID: 26393558

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