Ontology highlight
ABSTRACT:
SUBMITTER: Miller BK
PROVIDER: S-EPMC6333443 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Miller Brittany K BK Hughes Ryan R Ligon Lauren S LS Rigel Nathan W NW Malik Seidu S Anjuwon-Foster Brandon R BR Sacchettini James C JC Braunstein Miriam M
eLife 20190103
The SecA2 protein export system is critical for the virulence of <i>Mycobacterium tuberculosis</i>. However, the mechanism of this export pathway remains unclear. Through a screen for suppressors of a <i>secA2</i> mutant, we identified a new player in the mycobacterial SecA2 pathway that we named SatS for <u>S</u>ec<u>A</u>2 (<u>t</u>wo) <u>S</u>uppressor. In <i>M. tuberculosis</i>, SatS is required for the export of a subset of SecA2 substrates and for growth in macrophages. We further identify ...[more]