Ontology highlight
ABSTRACT:
SUBMITTER: Lochab S
PROVIDER: S-EPMC7162654 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lochab Savita S Singh Yogendra Y Sengupta Sagar S Nandicoori Vinay Kumar VK
eLife 20200330
(<i>Mtb</i>) produces inflections in the host signaling networks to create a favorable milieu for survival. The virulent <i>Mtb</i> strain, <i>Rv</i> caused double strand breaks (DSBs), whereas the non-virulent <i>Ra</i> strain triggered single-stranded DNA generation. The effectors secreted by SecA2 pathway were essential and adequate for the genesis of DSBs. Accumulation of DSBs mediated through <i>Rv</i> activates ATM-Chk2 pathway of DNA damage response (DDR) signaling, resulting in altered c ...[more]