Ontology highlight
ABSTRACT:
SUBMITTER: Sandelius A
PROVIDER: S-EPMC6333489 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sandelius Åsa Å Portelius Erik E Källén Åsa Å Zetterberg Henrik H Rot Uros U Olsson Bob B Toledo Jon B JB Shaw Leslie M LM Lee Virginia M Y VMY Irwin David J DJ Grossman Murray M Weintraub Daniel D Chen-Plotkin Alice A Wolk David A DA McCluskey Leo L Elman Lauren L Kostanjevecki Vesna V Vandijck Manu M McBride Jennifer J Trojanowski John Q JQ Blennow Kaj K
Alzheimer's & dementia : the journal of the Alzheimer's Association 20181012 1
<h4>Introduction</h4>The level of the presynaptic protein growth-associated protein 43 (GAP-43) in cerebrospinal fluid (CSF) has previously been shown to be increased in Alzheimer's disease (AD) and thus may serve as an outcome measure in clinical trials and facilitate earlier disease detection.<h4>Methods</h4>We developed an enzyme-linked immunosorbent assay for CSF GAP-43 and measured healthy controls (n = 43), patients with AD (n = 275), or patients with other neurodegenerative diseases (n = ...[more]