Ontology highlight
ABSTRACT:
SUBMITTER: Song D
PROVIDER: S-EPMC6334299 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Song Danjun D Luo Min M Dai Manyun M Bu Shizhong S Wang Weihua W Zhang Burong B Gonzalez Frank J FJ Liu Aiming A
Canadian journal of physiology and pharmacology 20160906 2
While gemfibrozil and fenofibrate are prescribed for anti-dyslipidemia treatment, a rational basis for the use of these drugs for treatment of dyslipidemia with concurrent metabolic syndrome has not been established. In this study, wild-type and Pparα-null mice were fed gemfibrozil- or fenofibrate-containing diets for 14 days. Urine output (24 h) was monitored, and urine, serum, and liver and kidney tissues were subjected to toxicity assessment. A 2-month challenge followed by a 2-week wash-out ...[more]