Ontology highlight
ABSTRACT:
SUBMITTER: Guo J
PROVIDER: S-EPMC6334536 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Guo Jing J Ozaki Iwata I Xia Jinghe J Kuwashiro Takuya T Kojima Motoyasu M Takahashi Hirokazu H Ashida Kenji K Anzai Keizo K Matsuhashi Sachiko S
Frontiers in oncology 20190109
While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this study, we examined the cell cycle regulators whose activation is affected by PDCD4 knockdown to investigate the contribution of PDCD4 to cell cycle regulation in three types of hepatoma cells: HepG2, Huh7 (mutant p53 and p16-deficient), and Hep3B (p53- and Rb-deficient). PDCD4 knockdown suppressed cell growth in all three cell ...[more]